Effects of Camphor on Enzymes, Hormones and Liver Tissues of Male White Mice

A.Desheesh, Mohmed; M.El-Shazly, Abd Allah; T. El-Deeb, Samir; H. El-Bann, Rania

doi:10.21608/asejaiqjsae.2017.4045

Effects of Camphor on Enzymes, Hormones and Liver Tissues of Male White Mice

Document Type : Original Article

Authors

Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University

10.21608/asejaiqjsae.2017.4045

Abstract

The natural product Camphor was structurally confirmed by elemental analysis (C, H) and spectroscopic measurements (U.V, I.R and ¹H-NMR). Camphor effects at sublethal doses (25, 50, 100 and 200 mg/kg) was tested on Plasma alanine amino-transferase (ALT), Aspartate amino-transferase (AST), Alkaline phosphatase (ALP) and Creatine Kinase (CK) blood enzymes;blood contents (WBC, RBC, Hg and HC); hormones (Testosterone and Follicle stimulating hormones (F.S.H) in addition to histopathological studies on liver tissues in male white mice.(Mus musculus var.albus)
The results indicated that the higher doses (100 and 200mg/kg) of camphor highly elevated the activities of the tested enzymes where as the lower doses caused lower changes of activities, in comparison with control. The tested camphor reduced testosterone and induced FSH levels which may be caused adverse and lesion effects of male mice reproductive system. The results showed also that WBC counts in male mice increased with increasing the tested doses of camphor. Finally, all the tested doses of camphor caused harmful changes in liver tissues of the tested white male mice according to the histopathological studies, in comparison with control.

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