Effect of Cinnamon, Propolis ,or Their Combination on Blood Glucose, Body Weight, Feed Efficiency Ratio and Relative Organs’ Weights in Rats with Diabetes Mellitus.

Document Type : Original Article

Authors

1 Home Economic Devision, Food Technology Department, Faculty of Agriculture, Cairo University

2 National Research Center, Giza

3 Agricultural Research Center – Giza

Abstract

Since ancient times, cinnamon and propolis have been used as folk medicine with reported beneficial effects on various clinical conditions. According to previous studies cinnamon and propolis may have a positive effect on glycemic control in diabetes mellitus. The present investigation was assigned to study the effect of cinnamon , propolis ,or their combination on blood glucose levels, body weight, feed efficiency ratio, body weight gain, and relative organs’ weights in diabetic rats compared to normal rats. Thirty male albino rats were randomly divided into two main groups. The first group (n=6) was considered as negative control non diabetic rats (group 1). The other group of rats (24 rats) was subjected for intravenous injection with recrystalyzed alloxan to induce hyperglycemia. The diabetic rats were randomly assigned to four equal groups. (Group 2) alloxan induced, untreated rats (n=6) were chosen as positive control and the other three groups (groups 3,4 and5) were given stomach tube with cinnamon, propolis ,or mixture of cinnamon and propolis, respectively. The concentration of dry material were  10 mg cinnamon /ml, and 3 mg propolis /ml  and mixture of 10 mg cinnamon and 3 mg propolis /ml for groups 3,4 and 5 respectively intragastrically once daily for 6 weeks(all groups were fed the basal diet). The results showed that treatment of diabetic rats with cinnamon, propolis and their combination led to decrease in serum glucose levels, compared with diabetic control group. The best treatment that improved serum glucose level was the combination of cinnamon &propolis. Regarding BWG% and FER of rats, there were very highly significant differences between positive and negative control groups. Body weight of normal control group rats was significantly higher than the three treated groups as well as the FER. But there was no significant difference between CINN, PROP and CINN+PROP in BWG either in BWG% or FER. There were no significant differences among the treated groups in liver weights. Also, there were insignificant differences among the mean values of relative weights for kidney, heart and spleen in the treated groups (3,4and5) .While, these values were significantly lower than those of diabetic control group. For relative brain weight, normal control group showed significantly higher value compared to the other groups. While, there were insignificant differences among the relative brain weights in the treated groups (3, 4&5) which demonstrated significantly lower values compared to those in the positive control group.
e use of mineral N- fertilizers and hence minimizing the adverse environment and human health in agro ecosystems.
 
 

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