Biochemical Alterations Induced by Abamectin in Albino Rats, Rattus norvegicus

Document Type : Original Article

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Dept. of Mammalian and Aquatic Toxicology, Central Agricultural Pesticides Laboratory (CAPL), Agricultural Research Center (ARC), Alexandria, Egypt

Abstract

Abamectin is a multipurpose pesticide, used as insecticide, nematicide, acaricide and antiparasitic agent in farm animals and pets. This study examined biochemical evaluation of liver and kidney functions as a result of abamectin toxicity in male albino rats. A single sublethal oral dose of 3.3mg Kg-1 body weight (1/3 LD50) was given. Hepatotoxicity was monitored at various times (4, 24 and 336 h) by quantitative analysis of the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, total protein, albumin, total bilrubin, triglycerides and total cholesterol levels. Creatinine and urea were used as the biomarkers of kidney damages.
Results showed that abamectin administration caused no clear interaction on total protein level, while AST, ALT and ALP activities, total bilrubin, triglycerides, cholesterol, creatinine and urea levels were increased. Whereas albumin level showed a significant reduction when compared with control group. 
In conclusion, the results indicated that changes in body and relative organ weights have been used as indicators of adverse effects of abamectin and also the alteration in tested enzymes activity and other parameters can be used as relevant biomarkers for monitoring toxicity due to abamectin exposure in mammals. 

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