Metaldehyde is a specific molluscicide for terrestrial snails and slugs. Histopathological changes induced by metaldehyde in the terrestrial snail E. vermiculata were investigated by light microscopy in order to study its cellular toxicity. Alterations in digestive gland included cellular infiltration, destruction of intertubular connective tissue, and extensive vacuolation in the cytoplasm of digestive cells. Degeneration and necrosis in the lining epithelium of the digestive tubules were also noticed. Irregular thickening in the outer covering muscular layer, thinning of basal layer, atrophy and degeneration of mucous cells were the most observed changes in dart gland. The histological alterations in the kidney were degeneration of nephrocytes, and an increase in the number and size of concretions in nephrocytes. Metaldehyde showed cytotoxic effects in all tested organs, that in turn leads to failure of the digestive, reproductive and excretory systems.
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