Mitochondrial Dysfunction and Response After Stressing by Aluminum Nanoparticles (AlNPs) of Helix sp

Document Type : Original Article

Authors

1 Laboratory of toxicology and ecosystems pathologies, Applied Biology department, Larbi Tebessi University, 12000, Tebessa, Algeria.

2 Applied biology department, tebessa university, Algeria

Abstract

The enhanced uses of nanoparticles in our daily life have been augmented according to industrial development. Indeed, the nature and the properties of nanoparticles make them a good choice in many products from food enhancers, drugs, nanomaterials, medicine, electronics and cosmetics.  
Our study is a trial on the effects of AlNPs (<10nm) on the mitochondrial status and possible dysfunction in detoxication organ of the snail Helix sp < em>. and to assess the impact of these nanomaterials on swelling, permeability and respiration of hepatopancreatic mitochondria.
Obtained results presents an increased activity of many mitochondrial metabolization enzymes (mitGST, mitCAT, mitMDA, mitGPx) and a decrease in GSH level. Thus, an increase in mitochondrial swelling and permeability have been showed with a slow rate of respiration level according to the controls group.
Finally, our results suggested that nanoparticles of aluminum affect directly the mitochondrial function by the perturbation of general metabolic status of snails exposed to 5 and 10μg /g of NPs of Al each 2 days.
 

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