Lorsban-Induced Changes in Haematological and Some Reproductive Parameters of Male Rats

M.I., Yousef; T.M.R, Lotfy

doi:10.21608/asejaiqjsae.2007.1892

Lorsban-Induced Changes in Haematological and Some Reproductive Parameters of Male Rats

Document Type : Original Article

Authors

Yousef M.I. ¹
Lotfy T.M.R ²

¹ Department of Environmental Studies, Institute of Graduate Studies & Research, University of Alexandria, Egypt

² Department of Home Economics, Faculty of Specific Education, University of Alexandria, Egypt

10.21608/asejaiqjsae.2007.1892

Abstract

The present study was carried out to investigate the possible toxic effects of different doses of lorsban on blood hematology, testosterone and thyroxin levels, and semen quality of male rats. Lorsban was given to rats by oral route at different doses (5, 10 and 15 mg/kg bw/day) for 6-weeks. The obtained results showed that all three doses of lorsban caused significant changes in the body weight gains and body weight. Relative weights of testes, epididymal and seminal vesicles were significantly (P<0.05) decreased in rats receiving 15 mg/kg only. Also, there was a decrease in mean corpuscular hemoglobin (MCH) and in mean corpuscular volume (MCV) in all experimental animals compared to control ones. While, there were insignificant changes in white blood cells (WBC), hemoglobin (Hb), hematocrit value (Ht), mean cell hemoglobin concentration (MCHC) and red blood cells (RBC) for rats treated with lorsban compared to control group. Meanwhile, it appeared that lorsban caused a rise in thrombocyte (PL) number in individuals treated with the highest dose. Similarly, the highest dose induced significant (p < 0.001) decrease in spermatids number, sperm count and sperm transit rate with an observed impairment of daily sperm production. Such observations were coupled with a reduction in plasma testosterone levels and an increase in plasma free thyroxin (FT4) levels compared to controls. It is, therefore, assumed that treatment with lorsban up to 15 mg/kg bw alters both hematological and reproductive parameters in rats, and subsequently affects fertility.

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