Antimutagenic Effect of Camil Milk Using Dominant Lethal Mutation Assay in Mice

During recent years, considerable effort have been focused on using antimutagens to modulate the genotoxic effects of the mutagenic antineoplastic drugs. Therefore, much attention has been paid to the research of naturally occurring agents (especially in diet) that are able to stimulate defense mechanisms of the organism.
Therefore, the aim of the present study is to evaluate the possible protective (antimutagenic) role of Camel milk against the genotoxic effects of a widely used antineoplastic drug “cisplatin” in gametic cells of male mice in vivo.
The 50 adult male Swiss albino mice were divided into five groups:
Gr. I: treated with distilled water and considered as control group.
Gr. II: treated with camel milk (33ml/kg, b.wt.).
Gr. III: treated previously with cisplatin (0.5mg/kg, b.wt.).
Gr. IV: treated with camel milk and followed after 2h. with cisplatin (33ml/kg  0.5mg/kg, b.wt.).
Gr. V: treated with camel milk and cisplatin at the same time (33ml/kg + 0.5mg/kg, b.wt.).
The analysis of data obtained from the dominant lethal assay revealed that the drug was highly effective in inducing dominant lethality after treatment with cisplatin, especially in the first, second and fifth weeks. This implies that the spermatozoa, late spermatid and primary spermatocytes were the most sensitive and highly affected stages by this treatment.
On the other hand, pre & simultaneous treatments with camel milk treatment with cisplatin showed a noticeable decrease in the dominant lethal values in the same stages affected by cisplatin treatment only. It is obviously that the pre- treatment with camel milk and followed by the drug was the more effective treatment in reducing the dominant lethal values than that of the simultaneous treatment observed in the majority of examined weeks. This protective effect of camel milk could be attributed to the scavenging ability to trap free radicals of some of its components like vitamins and minerals. or it has some antioxidant effect.